Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | TLR2 | O60603 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7566557 | 0.80 | KMT2A (0.39) | KMT2ALMNAPOLBPRMT5WDR77 | |
| SCHEMBL6303593 | 0.71 | CASR (0.39) | KMT2ALMNAPOLBGSK3BALDH1A1 | |
| SCHEMBL7465483 | 0.66 | MAPT (0.35) | KMT2ALMNAPOLBALDH1A1GAA | |
| SCHEMBL6303591 | 0.66 | ADRB3 (0.42) | KMT2ALMNAPOLBGSK3BALDH1A1 | |
| SCHEMBL28102683 | 0.60 | MEN1 (0.66) | KMT2ALMNAPOLBPRMT5WDR77 | |
| SCHEMBL28451372 | 0.60 | GAA (0.49) | KMT2AALDH1A1GAASMN1; SMN2HPGD | |
| SCHEMBL28831614 | 0.60 | LMNA (0.61) | KMT2ALMNAPOLBPRMT5WDR77 | |
| SCHEMBL5506646 | 0.60 | MAPT (0.75) | KMT2ALMNAALDH1A1GAAMAPT | |
| SCHEMBL7916058 | 0.59 | TMEM97 (0.62) | KMT2ALMNAPRMT5WDR77ALDH1A1 | |
| SCHEMBL11859482 | 0.58 | LMNA (0.46) | KMT2ALMNAPOLBALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214313-A2 | HETEROARYLOXY PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017989-A2 | HETEROARYLOXYPROPANOLAMINES AS BETA3-ADRENERGIC RECEPTOR AGONISTS | SANOFI-SYNTHELABO (FR) | 2001-03-15 | — | — | WO | disclosed |