Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | TLR4 | O00206 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473202 | 0.89 | HRH3 (0.34) | MAPTRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7465477 | 0.82 | MAPT (0.35) | MAPTRAB9ANPC1NFKB1MAPK1 | |
| SCHEMBL7470311 | 0.80 | MBTPS1 (0.33) | RAB9ANPC1HRH3POLBLMNA | |
| SCHEMBL7469212 | 0.76 | MAOB (0.35) | MAPTRAB9ANPC1ACHESMN1; SMN2 | |
| SCHEMBL7473197 | 0.71 | HRH3 (0.33) | MAPTTLR4TLR2ALDH1A1HRH3 | |
| SCHEMBL7822124 | 0.67 | JMJD6 (0.36) | MAPTGAAKDM4EKMT2ALMNA | |
| SCHEMBL6301403 | 0.66 | HRH3 (0.45) | MAPTRAB9ANPC1NFKB1MAPK1 | |
| SCHEMBL6301089 | 0.66 | HRH3 (0.45) | MAPTRAB9ANPC1NFKB1MAPK1 | |
| SCHEMBL7566562 | 0.66 | KMT2A (0.37) | MAPTRAB9ANPC1TLR2ALDH1A1 | |
| SCHEMBL7470148 | 0.65 | LMNA (0.34) | MAPTRAB9AALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214313-A2 | HETEROARYLOXY PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017989-A2 | HETEROARYLOXYPROPANOLAMINES AS BETA3-ADRENERGIC RECEPTOR AGONISTS | SANOFI-SYNTHELABO (FR) | 2001-03-15 | — | — | WO | disclosed |