Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 17/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7566064 | 0.89 | AKR1B1 (0.62) | AKR1B1HSD11B1ALDH1A1GAA | |
| SCHEMBL7565197 | 0.88 | AKR1B1 (0.60) | AKR1B1HSD11B1ALDH1A1GAA | |
| SCHEMBL9391497 | 0.82 | AKR1B1 (0.50) | AKR1B1 | |
| SCHEMBL7564397 | 0.81 | AKR1B1 (0.39) | AKR1B1ALDH1A1 | |
| SCHEMBL1349195 | 0.80 | MAP3K14 (0.40) | AKR1B1 | |
| SCHEMBL9394789 | 0.76 | AKR1B1 (0.47) | AKR1B1HSD11B1 | |
| Lithium Ion SCHEMBL7565191 | 0.75 | AKR1B1 (0.46) | AKR1B1 | |
| SCHEMBL5709378 | 0.74 | HSD11B1 (0.41) | AKR1B1HSD11B1ALDH1A1 | |
| SCHEMBL9392173 | 0.74 | AKR1B1 (0.51) | AKR1B1 | |
| SCHEMBL9391406 | 0.74 | AKR1B1 (0.51) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0987248-B1 | Amide derivatives and their therapeutic use | WELLCOME FOUND (GB) | 2002-09-04 | — | — | EP | disclosed |
| EP-0699180-B1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | WELLCOME FOUND (GB) | 2000-11-22 | — | — | EP | disclosed |
| US-6124284-A | REDUCED SIDE EFFECTS | GLAXO WELLCOME INC. (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0987248-A1 | Amide derivatives and their therapeutic use | THE WELLCOME FOUNDATION LIMITED (GB) | 2000-03-22 | — | — | EP | disclosed |
| US-5872118-A | RELAXATION OF SKELETAL MUSCLE IN SPASTIC, HYPERTONIC AND HYPERKINETIC CONDITIONS | GLAXO WELLCOME INC. (US) | 1999-02-16 | — | — | US | disclosed |
| CN-1041720-C | Bicyclic amide derivatives, preparation method thereof, pharmaceutical composition and pharmaceutical application thereof | WELLCOME FOUND (GB) | 1999-01-20 | — | — | CN | disclosed |
| CN-1125938-A | Bicyclic amide derivatives and their use as muscle relaxants | WELLCOME FOUND (GB) | 1996-07-03 | — | — | CN | disclosed |
| EP-0699180-A1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994026692-A1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-24 | — | — | WO | disclosed |
| WO-1994026693-A1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-24 | — | — | WO | disclosed |