Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | SI | P14410 | 3/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7567252 | 0.85 | CYP19A1 (0.53) | CYP19A1FAAHMGLLKMT2AREV1 | |
| SCHEMBL21051428 | 0.84 | PDE10A (0.51) | CYP19A1FAAHMGLLREV1NPC1 | |
| SCHEMBL7565376 | 0.82 | FFAR1 (0.55) | TP53MAPT | |
| SCHEMBL5372077 | 0.81 | CYP19A1 (0.48) | CYP19A1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5378962 | 0.80 | KMT2A (0.64) | CYP19A1KMT2AALDH1A1LMNAGAA | |
| SCHEMBL7564649 | 0.79 | MAOB (0.45) | KMT2ANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL7595267 | 0.78 | CNR1 (0.47) | CYP19A1FAAHMGLLNPC1RAB9A | |
| SCHEMBL5384888 | 0.77 | HDAC1 (0.55) | CYP19A1FAAHMGLLKMT2ANPC1 | |
| SCHEMBL5377556 | 0.77 | KMT2A (0.52) | KMT2ANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL5377099 | 0.76 | FFAR1 (0.56) | ALDH1A1MAPTGAAPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |