Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11049665 | 0.84 | MTOR (0.33) | KMT2AMEN1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL729737 | 0.80 | HPGD (0.42) | KMT2AMEN1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL6596072 | 0.78 | KMT2A (0.40) | KMT2AMEN1ALDH1A1KDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL7340468 | 0.76 | KMT2A (0.39) | KMT2AMEN1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL672597 | 0.75 | NOTUM (0.42) | KMT2AMEN1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL2780530 | 0.75 | POLB (0.41) | KMT2AMEN1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL1436268 | 0.75 | LOXL2 (0.40) | KMT2AMEN1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL27641126 | 0.75 | ALPL (0.41) | KMT2AKDM4ECYP1A2MTORADK | |
| SCHEMBL30670275 | 0.74 | MTOR (0.38) | KMT2AMEN1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL2092717 | 0.74 | MTOR (0.38) | KMT2AMEN1ALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6002005-A | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands | NEUROGEN CORPORATION (US) | 1999-12-14 | — | — | US | disclosed |
| US-5760234-A | THERAPY FOR NERVOUS SYSTEM DISORDERS | NEUROGEN CORPORATION (US) | 1998-06-02 | — | — | US | disclosed |
| US-5750700-A | COMPOUNDS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS SCHIZOPHRENIA, NEUROLEPTIC AGENTS FOR BINDING TO DOPAMINE RECEPTORS | NEUROGEN CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| WO-1996016057-A1 | CERTAIN 1-SUBSTITUTED AMINOMETHYL IMIDAZOLE AND PYRROLE DERIVATIVES; NOVEL DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1996-05-30 | — | — | WO | disclosed |
| US-5478934-A | Treating central nervous system disorders | NEUROGEN CORPORATION | 1995-12-26 | — | — | US | disclosed |