Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.44 |
| ▸ | DHPS | P49366 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | EDNRB | P24530 | 2/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570877 | 0.88 | EDNRB (0.46) | EDNRACYP2C9MAPTKMT2ACYP1A2 | |
| SCHEMBL7575135 | 0.85 | L3MBTL1 (0.41) | EDNRADHPSMAPTMEN1KMT2A | |
| SCHEMBL7573385 | 0.83 | EDNRA (0.36) | EDNRACYP2C9MAPTMEN1KMT2A | |
| SCHEMBL7573324 | 0.81 | EDNRA (0.62) | EDNRADHPSCYP2C9EDNRB | |
| SCHEMBL7566550 | 0.79 | EDNRB (0.60) | CYP2C9MAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7569355 | 0.74 | EDNRA (0.62) | EDNRADHPSCYP2C9MAPTGAA | |
| SCHEMBL7568220 | 0.74 | EDNRA (0.62) | EDNRADHPSEDNRB | |
| SCHEMBL7567459 | 0.72 | EDNRA (0.77) | EDNRADHPSEDNRB | |
| SCHEMBL7568031 | 0.72 | EDNRB (0.65) | EDNRADHPSCYP2C9MAPTMEN1 | |
| SCHEMBL7567961 | 0.69 | EDNRA (0.55) | EDNRADHPSCYP2C9MAPTEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799206-B1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| EP-0799206-A1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019455-A1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | disclosed |