Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 9/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | EDNRB | P24530 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7574322 | 0.90 | CYP2C9 (0.35) | MEN1KMT2ACYP2C9EDNRBMAPT | |
| SCHEMBL7568975 | 0.85 | EDNRA (0.47) | EDNRACYP2C9EDNRBALDH1A1 | |
| SCHEMBL7568035 | 0.83 | EDNRA (0.44) | EDNRAMEN1KMT2ACYP2C9EDNRB | |
| SCHEMBL7565835 | 0.80 | PDE4B (0.39) | MEN1KMT2AALDH1A1PDE4B | |
| SCHEMBL7565796 | 0.79 | EDNRA (0.47) | EDNRAKMT2ACYP2C9EDNRBMAPT | |
| SCHEMBL7565509 | 0.79 | ALDH1A1 (0.40) | MEN1KMT2AMAPTALDH1A1PDE4B | |
| SCHEMBL7568989 | 0.78 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL7568663 | 0.78 | EDNRB (0.48) | EDNRAMEN1KMT2ACYP2C9EDNRB | |
| SCHEMBL7570847 | 0.76 | ALDH1A1 (0.43) | EDNRAMAPTUSP2GAAALDH1A1 | |
| SCHEMBL7570796 | 0.73 | EDNRA (0.55) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799206-B1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| EP-0799206-A1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019455-A1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | disclosed |