Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.57 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498290 | 0.76 | CYP11B1 (0.45) | IKBKBCYP11B1CYP11B2GABRA1GABRG2 | |
| SCHEMBL2096573 | 0.75 | PDE4B (0.55) | IKBKBFYNSQORMAPTMEN1 | |
| SCHEMBL7549309 | 0.73 | IKBKB (0.51) | IKBKBMAPK14NOTUMSQORGABRA1 | |
| SCHEMBL7576650 | 0.73 | MAPK14 (0.44) | IKBKBFYNMAPK14BRAFNOTUM | |
| SCHEMBL7544094 | 0.73 | IKBKB (0.58) | IKBKBNOTUMCYP11B1CYP11B2SQOR | |
| SCHEMBL12325398 | 0.73 | PDE4B (0.56) | IKBKBFYNSQORMAPTMEN1 | |
| Diphenylether SCHEMBL28242079 | 0.71 | NOTUM (0.67) | MAPK14NOTUMCYP11B1CYP11B2MAPK13 | |
| SCHEMBL17123367 | 0.68 | NOTUM (0.62) | IKBKBMAPK14NOTUMCHUKIKBKE | |
| SCHEMBL2094797 | 0.68 | LTA4H (0.56) | FYNBRAFTUBB4ATUBBTUBA3C | |
| SCHEMBL7011494 | 0.68 | NOTUM (0.61) | MAPK14NOTUMCYP11B1CYP11B2MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885193-A1 | TRIARYL COMPOUNDS | Novartis AG (CH) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032853-A1 | TRIARYL COMPOUNDS | NOVARTIS AG (CH) | 1997-09-12 | — | — | WO | disclosed |