Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 13/20 | 0.65 |
| ▸ | TNKS2 | Q9H2K2 | 13/20 | 0.65 |
| ▸ | PARP1 | P09874 | 11/20 | 0.65 |
| ▸ | WNT3A | P56704 | 2/20 | 0.53 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.52 |
| ▸ | COMT | P21964 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775381 | 0.85 | TNKS (0.63) | TNKSTNKS2PARP1PARP2RAB9A | |
| SCHEMBL15775567 | 0.85 | PARP1 (0.61) | TNKSTNKS2PARP1 | |
| SCHEMBL15775277 | 0.84 | TNKS (0.65) | TNKSTNKS2PARP1WNT3APARP2 | |
| SCHEMBL15775644 | 0.83 | TNKS (0.60) | TNKSTNKS2PARP1 | |
| SCHEMBL15775482 | 0.82 | PARP1 (0.63) | TNKSTNKS2PARP1RAB9A | |
| SCHEMBL15775691 | 0.82 | TNKS (0.63) | TNKSTNKS2PARP1 | |
| SCHEMBL15775320 | 0.82 | TNKS (0.63) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL15775241 | 0.82 | TNKS (0.63) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL15775334 | 0.81 | TNKS (0.67) | TNKSTNKS2PARP1WNT3APARP2 | |
| SCHEMBL7568265 | 0.79 | TNKS (1.00) | TNKSTNKS2PARP1WNT3APARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |