Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042198 | 0.92 | CHRM2 (0.40) | CHRM2CHRM4CHRM1CHRM3MITF | |
| SCHEMBL7560345 | 0.90 | CHRM2 (0.39) | CHRM2CHRM4CHRM1CHRM3DPP4 | |
| SCHEMBL6041390 | 0.82 | CHRM2 (0.39) | CHRM2CHRM4CHRM1CHRM3NPSR1 | |
| SCHEMBL6042563 | 0.75 | CHRM2 (0.37) | CHRM2CHRM4CHRM1CHRM3NPSR1 | |
| SCHEMBL7553812 | 0.67 | CHRM2 (0.36) | CHRM2CHRM4CHRM1CHRM3HTT | |
| SCHEMBL6042380 | 0.66 | CHRM2 (0.35) | CHRM2CHRM4CHRM1CHRM3HTT | |
| SCHEMBL6042787 | 0.65 | REN (0.45) | KMT2AALDH1A1TP53MDM2 | |
| SCHEMBL6041482 | 0.65 | MDM2 (0.36) | TP53MDM2GRIN2B | |
| SCHEMBL6042189 | 0.64 | REN (0.43) | — | |
| SCHEMBL6042700 | 0.62 | CHRM2 (0.39) | CHRM2CHRM4CHRM1CHRM3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076440-A2 | METHODS OF TREATING ALZHEIMER'S DISEASE WITH PIPERIDIN DERIVATES | ELAN PHARMACEUTICALS, INC. (US) | 2002-10-03 | — | — | WO | disclosed |