Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.71 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.58 |
| ▸ | MPO | P05164 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | NQO2 | P16083 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129785 | 0.85 | MTNR1A (0.77) | MTNR1AMTNR1BKMT2AMEN1MAPT | |
| SCHEMBL8020879 | 0.85 | HTR2A (0.67) | MTNR1AMTNR1BKMT2AMEN1MAPT | |
| SCHEMBL4490583 | 0.83 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AMEN1MAPT | |
| SCHEMBL30630306 | 0.83 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AMEN1MAPT | |
| SCHEMBL14368085 | 0.81 | MTNR1A (0.78) | MTNR1AMTNR1BKMT2AMEN1MAPT | |
| SCHEMBL16137407 | 0.81 | MTNR1A (0.81) | MTNR1AMTNR1BKMT2AMEN1MAPT | |
| SCHEMBL5616635 | 0.81 | MTNR1A (0.85) | MTNR1AMTNR1BKMT2AMEN1MAPT | |
| SCHEMBL32678246 | 0.78 | MTNR1A (0.79) | MTNR1AMTNR1BKMT2AMEN1MAPT | |
| SCHEMBL4854372 | 0.78 | HTR2A (0.63) | MTNR1AMTNR1BKMT2AMEN1MAPT | |
| SCHEMBL14301523 | 0.78 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-A4 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | EP | claimed |
| EP-1082127-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999056765-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-11-11 | — | — | WO | claimed |