Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.64 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.64 |
| ▸ | HTR6 | P50406 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8694538 | 0.90 | MTNR1A (0.64) | HTR2AMEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL16495066 | 0.90 | MTNR1A (0.70) | HTR2AMEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL4854372 | 0.85 | HTR2A (0.63) | HTR2AMEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL5616636 | 0.85 | MTNR1A (0.69) | HTR2AMEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL7568602 | 0.85 | MTNR1A (0.71) | HTR2AMEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL23226241 | 0.84 | MTNR1A (0.67) | HTR2AMEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL5023884 | 0.83 | HTR2A (0.83) | HTR2AMEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL28681119 | 0.82 | HTR2A (0.64) | HTR2AKMT2AMTNR1AMTNR1BMPO | |
| SCHEMBL14191591 | 0.82 | HTR2A (0.71) | HTR2AMEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL5363878 | 0.81 | HTR2A (0.66) | HTR2AMEN1KMT2AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745584-B1 | Arylalkyl(thio) carboxamides compounds with affinity for melatonine receptors, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-01-05 | — | — | EP | disclosed |
| US-5721276-A | TREATING DISORDERS OF MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-02-24 | — | — | US | disclosed |
| EP-0745584-A1 | Arylalkyl(thio) carboxamides compounds with affinity for melatonine receptors, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |