SCHEMBL7568657

SCHEMBL7568657

O=C(N[CH]c1ccccc1)C1CNCCN1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MC4R P32245 2/20 0.38
CNR2 P34972 1/20 0.37
HPGD P15428 1/20 0.35
CTSC P53634 1/20 0.34
POLB P06746 2/20 0.33
HDAC3 O15379 2/20 0.33
HDAC4 P56524 2/20 0.33
HDAC1 Q13547 2/20 0.33
HDAC2 Q92769 2/20 0.33
HDAC8 Q9BY41 2/20 0.33
HDAC6 Q9UBN7 2/20 0.33
MMP1 P03956 1/20 0.33
MMP2 P08253 1/20 0.33
MMP9 P14780 1/20 0.33
RECQL P46063 1/20 0.33
JAK3 P52333 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
MAPT P10636 1/20 0.33
RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8916132 0.81 CTSC (0.51) CTSCPOLBHTR2CHTR2B
SCHEMBL11860116 0.77 DPP4 (0.49) HPGDPOLBHDAC6JAK3MAPT
SCHEMBL13604501 0.77 DPP4 (0.49) HPGDPOLBHDAC6JAK3MAPT
SCHEMBL27928186 0.77 DPP4 (0.49) HPGDPOLBHDAC6JAK3MAPT
SCHEMBL17144545 0.77 MC4R (0.63) MC4RHPGDJAK3HTR2CHTR2B
SCHEMBL7561876 0.76 MC4R (0.46) MC4RHPGDPOLBHDAC3HDAC4
SCHEMBL5633855 0.73 LMNA (0.51) CNR2CTSCMAPT
SCHEMBL5634616 0.71 HDAC3 (0.46) CNR2POLBHDAC3HDAC4HDAC1
SCHEMBL12479526 0.71 GLA (0.43) POLBHTR2CHTR2BRAB9A
SCHEMBL27973372 0.71 CNR2 (0.41) CNR2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002067654-A3 6-SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES USEFUL AS CYCLIN DEPENDENT KINASE INHIBITORS BRISTOL MYERS SQUIBB PHARMA CO (US) 2002-10-31 WO claimed
WO-2002067654-A3 6-SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES USEFUL AS CYCLIN DEPENDENT KINASE INHIBITORS BRISTOL MYERS SQUIBB PHARMA CO (US) 2002-10-31 WO disclosed