SCHEMBL7568707

SCHEMBL7568707

CC(C)(C)[Si](OCc1nc2c(C(=O)O)cccc2[nH]1)(c1ccccc1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.46
HPGD P15428 1/20 0.46
DHODH Q02127 15/20 0.45
PARP1 P09874 2/20 0.44
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
PTGES O14684 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7480003 0.90 RIPK1 (0.47) KDM4EPARP1PTGES
SCHEMBL7485939 0.82 CHEK1 (0.46) CYP1A2CYP2C9
SCHEMBL7954447 0.80 PKN1 (0.42) KDM4ECYP1A2CYP2C9
SCHEMBL18663648 0.79 CBFB (0.40) CYP1A2CYP2C9
SCHEMBL7426451 0.75 PARP1 (0.36) KDM4EHPGDDHODHPARP1
SCHEMBL1564661 0.75 HTT (0.44) CYP2C9
SCHEMBL15808131 0.75 KDM4E (0.56) KDM4EHPGDDHODHPARP1
Hydrochloric Acid SCHEMBL4885974 0.73 KDM4E (0.55) KDM4EHPGDDHODHPARP1
SCHEMBL4260461 0.73 KDM4E (0.57) KDM4EHPGDDHODHPARP1
SCHEMBL9224298 0.72 KDM4E (0.54) KDM4EHPGDDHODHPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6316482-B1 FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-11-13 US disclosed
US-6207693-B1 Benzamide derivatives having a vasopressin antagonistic activity FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-03-27 US disclosed
EP-0946519-A1 BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-10-06 EP disclosed
WO-1998024771-A1 BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-06-11 WO disclosed