Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 9/20 | 0.78 |
| ▸ | ACE | P12821 | 8/20 | 0.78 |
| ▸ | CPA1 | P15085 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 3/20 | 0.47 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017267 | 0.88 | MME (1.00) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL7567320 | 0.87 | MME (0.66) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL8027102 | 0.85 | MME (0.86) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL7568168 | 0.84 | MME (0.60) | MMEACECPA1ACE2MEN1 | |
| SCHEMBL7566349 | 0.84 | MME (0.57) | MMEACECPA1ACE2MEN1 | |
| SCHEMBL8029453 | 0.84 | MME (0.84) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL8017444 | 0.83 | MME (0.83) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL7567832 | 0.83 | MME (0.73) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL7567827 | 0.83 | MME (0.73) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL27543297 | 0.83 | MME (0.70) | MMEACECPA1ACE2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798291-B1 | NOVEL 1,3-DIALKYLUREA DERIVATIVES | SANTEN PHARMACEUTICAL CO LTD (JP) | 2002-09-11 | — | — | EP | disclosed |
| US-5968980-A | ENDOPEPTIDASE 24.11 INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| EP-0798291-A1 | NOVEL 1,3-DIALKYLUREA DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1997-10-01 | — | — | EP | disclosed |