Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 4/20 | 0.38 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL27759607 | 1.00 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL571532 | 1.00 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL6131060 | 1.00 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL4646062 | 0.98 | ALDH1A1 (0.71) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL9538164 | 0.98 | ALDH1A1 (0.71) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL23012734 | 0.98 | ALDH1A1 (0.71) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL7742094 | 0.98 | ALDH1A1 (0.71) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL9538158 | 0.98 | ALDH1A1 (0.71) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL7742087 | 0.98 | ALDH1A1 (0.71) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL8056530 | 0.98 | ALDH1A1 (0.71) | ALDH1A1TSHRLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120130470-A | Processing method for quick dyeing and fresh-keeping cooperative treatment of cut flowers of starfish and special preparation | 云南花益美生物科技有限责任公司 | 2025-06-13 | — | — | CN | claimed |
| CN-116496360-A | Tandem peptide and method for preparing multiple bioactive peptides simultaneously by using recombinant escherichia coli | 安徽普利药业有限公司 | 2023-07-28 | — | — | CN | claimed |
| CN-113578957-B | Method for improving degradation rate of pyrimethanil serving as bactericide | 江苏省农业科学院 | 2023-03-31 | — | — | CN | claimed |
| CN-115633780-A | Method for improving lipid-lowering activity of pine pollen by using rhizopus oryzae fermentation | 烟台新时代健康产业有限公司 | 2023-01-24 | — | — | CN | claimed |
| CN-114957494-A | Process for extracting protein in polygonatum polysaccharide by adopting double aqueous phases | 江苏农牧科技职业学院 | 2022-08-30 | — | — | CN | claimed |
| CN-113577044-A | An inhalant solution containing andrographolide sulfonate or its salt for treating new type coronavirus pneumonia, and its preparation method | 江西青峰药业有限公司 | 2021-11-02 | — | — | CN | claimed |
| CN-113578957-A | Method for improving degradation rate of pyrimethanil serving as bactericide | 江苏省农业科学院 | 2021-11-02 | — | — | CN | claimed |
| CN-109652988-B | Complex enzyme preparation for improving washing effect of jeans wear and application thereof | 武汉新华扬生物股份有限公司 | 2021-09-21 | — | — | CN | claimed |
| CN-111793142-A | Ultrasonic-assisted synergistic compound enzyme extraction process for polygonatum sibiricum polysaccharide | 江苏农牧科技职业学院 | 2020-10-20 | — | — | CN | claimed |
| CN-111315886-A | Recombinant human basic fibroblast growth factor (rh-bFGF) and pharmaceutical composition containing rh-bFGF | 珠海亿胜生物制药有限公司 | 2020-06-19 | — | — | CN | claimed |
| CN-104514157-B | A kind of preparation method based on the silk broadcloth stamp nanometer ink that cellulose nanospheres is dispersant | 杭州万事利丝绸科技有限公司 | 2016-10-05 | — | — | CN | claimed |
| CN-105837835-A | Method for improving oil-in-water emulsion stability | 江苏四新科技应用研究所股份有限公司 | 2016-08-10 | — | — | CN | claimed |
| CN-110072872-B | Vaccine for preventing infection caused by Brucella organisms | 环境、食品及农村国务部 | 2024-01-16 | — | — | CN | disclosed |
| CN-116496360-A | Tandem peptide and method for preparing multiple bioactive peptides simultaneously by using recombinant escherichia coli | 安徽普利药业有限公司 | 2023-07-28 | — | — | CN | disclosed |
| CN-116139083-A | Low-concentration atropine nanoemulsion and preparation method and application thereof | 沈阳药科大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-116102647-A | Antibody combination for detecting transforming growth factor-beta 1 and application thereof | 江苏睿源生物技术有限公司 | 2023-05-12 | — | — | CN | disclosed |
| EP-0683670-A1 | WOUND-HEALING COMPOSITIONS CONTAINING IODINE AND A NON-REDUCING SUGAR | MCCONN-STERN, Rita (IE) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994017811-A1 | WOUND-HEALING COMPOSITIONS CONTAINING IODINE AND A NON-REDUCING SUGAR | MCCONN STERN RITA (IE) | 1994-08-18 | — | — | WO | disclosed |
| EP-0199992-B1 | ADSORPTION-RESISTANT PEPTIDE COMPOSITION AND USE OF BENZALKONIUM OR BENZETHONIUM CHLORIDE IN THE PREPARATION THEREOF | Eisai Co., Ltd. (JP) | 1990-08-29 | — | — | EP | disclosed |
| EP-0199992-A1 | Adsorption-resistant peptide composition and use of benzalkonium or benzethonium chloride in the preparation thereof | Eisai Co., Ltd. (JP) | 1986-11-05 | — | — | EP | disclosed |