Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 13/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.31 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7562111 | 0.83 | PTGS1 (0.42) | PTGS1PTGS2ALOX5 | |
| SCHEMBL7564292 | 0.80 | PTGS2 (0.43) | PTGS1PTGS2ALOX5NOTUM | |
| SCHEMBL7564450 | 0.80 | PTGS2 (0.67) | PTGS1PTGS2ALOX5 | |
| SCHEMBL672713 | 0.70 | PTGS2 (0.35) | PTGS1PTGS2ALOX5NOTUM | |
| SCHEMBL7571234 | 0.70 | PTGS2 (0.35) | PTGS1PTGS2ALOX5NOTUM | |
| SCHEMBL17612789 | 0.68 | SSTR5 (0.39) | PTGS1PTGS2ALOX5NOTUM | |
| SCHEMBL11404383 | 0.68 | TDP1 (0.46) | — | |
| SCHEMBL670524 | 0.67 | PTGS2 (0.40) | PTGS1PTGS2ALOX5NOTUM | |
| SCHEMBL6154102 | 0.67 | PTGS2 (0.35) | PTGS1PTGS2ALOX5NOTUM | |
| SCHEMBL6156608 | 0.63 | PTGS2 (0.32) | PTGS1PTGS2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228055-A1 | DIHYDROAMINOBENZO[B]- AND [C]FURANS AS RETINOID-LIKE AGENTS | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012618-A1 | DIHYDROAMINOBENZO[B]- AND [C]FURANS AS RETINOID-LIKE AGENTS | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6093838-A | FOR TREATING SKIN-RELATED DISEASES, INCLUDING ACTINIC KERATOSES, ARSENIC KERATOSES, ECZEMA | ALLERGAN SALES, INC. (US) | 2000-07-25 | — | — | US | disclosed |