Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 14/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 9/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672713 | 0.77 | PTGS2 (0.35) | PTGS2PTGS1ALOX5SSTR5NOTUM | |
| SCHEMBL7568789 | 0.77 | PTGS1 (0.33) | PTGS2PTGS1ALOX5NOTUM | |
| SCHEMBL6669568 | 0.77 | PTGS2 (0.55) | PTGS2PTGS1ALOX5 | |
| SCHEMBL7564634 | 0.77 | PTGS2 (0.40) | PTGS2PTGS1ALOX5NOTUM | |
| SCHEMBL17612789 | 0.74 | SSTR5 (0.39) | PTGS2PTGS1ALOX5SSTR5NOTUM | |
| SCHEMBL6154102 | 0.73 | PTGS2 (0.35) | PTGS2PTGS1ALOX5SSTR5NOTUM | |
| SCHEMBL670524 | 0.73 | PTGS2 (0.40) | PTGS2PTGS1ALOX5NOTUM | |
| SCHEMBL16812210 | 0.71 | ACHE (0.37) | — | |
| SCHEMBL7569147 | 0.70 | PTGS1 (0.43) | PTGS2PTGS1ALOX5NOTUM | |
| SCHEMBL6756543 | 0.70 | PTGS2 (0.40) | PTGS2PTGS1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228055-A1 | DIHYDROAMINOBENZO[B]- AND [C]FURANS AS RETINOID-LIKE AGENTS | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012618-A1 | DIHYDROAMINOBENZO[B]- AND [C]FURANS AS RETINOID-LIKE AGENTS | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6093838-A | FOR TREATING SKIN-RELATED DISEASES, INCLUDING ACTINIC KERATOSES, ARSENIC KERATOSES, ECZEMA | ALLERGAN SALES, INC. (US) | 2000-07-25 | — | — | US | disclosed |