SCHEMBL7569362

SCHEMBL7569362

CSc1ccc(/C=C/c2cc(F)cc(F)c2)cc1

nearest known ligand 0.63

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 10/20 0.58
CYP1A2 P05177 10/20 0.58
CYP1B1 Q16678 10/20 0.58
ALDH1A1 P00352 1/20 0.47
FBP1 P09467 1/20 0.46
PTGS1 P23219 1/20 0.46
PTGS2 P35354 1/20 0.46
PTGES2 Q9H7Z7 2/20 0.45
CYP17A1 P05093 1/20 0.43
CYP21A2 P08686 1/20 0.43
CYP11B1 P15538 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7569369 1.00 CYP1A1 (0.58) CYP1A1CYP1A2CYP1B1ALDH1A1FBP1
SCHEMBL7568987 0.85 CYP1A1 (0.59) CYP1A1CYP1A2CYP1B1ALDH1A1FBP1
SCHEMBL7568993 0.85 CYP1A1 (0.59) CYP1A1CYP1A2CYP1B1ALDH1A1FBP1
SCHEMBL7566367 0.83 NFE2L2 (0.67) CYP1A1CYP1A2CYP1B1PTGS1PTGS2
SCHEMBL7566377 0.83 NFE2L2 (0.67) CYP1A1CYP1A2CYP1B1PTGS1PTGS2
SCHEMBL13790243 0.82 CYP1A1 (0.71) CYP1A1CYP1A2CYP1B1ALDH1A1FBP1
SCHEMBL7567897 0.82 CYP1A1 (0.71) CYP1A1CYP1A2CYP1B1ALDH1A1FBP1
SCHEMBL8367958 0.82 CYP1A1 (0.71) CYP1A1CYP1A2CYP1B1ALDH1A1FBP1
SCHEMBL13790333 0.82 CYP1A1 (0.71) CYP1A1CYP1A2CYP1B1ALDH1A1FBP1
SCHEMBL7566335 0.78 NFE2L2 (0.63) CYP1A1CYP1A2CYP1B1ALDH1A1FBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0889878-B1 BISARYLCYCLOBUTENE DERIVATES AS CYCLOOXYGENASE INHIBITORS MERCK FROSST CANADA INC (CA) 2002-09-04 EP disclosed
EP-0889878-A1 BISARYLCYCLOBUTENE DERIVATES AS CYCLOOXYGENASE INHIBITORS MERCK FROSST CANADA INC. (CA) 1999-01-13 EP disclosed
US-5817700-A ANTIINFLAMMATORY AGENTS MERCK FROSST CANADA, INC. (CA) 1998-10-06 US disclosed
WO-1997036863-A1 BISARYLCYCLOBUTENE DERIVATES AS CYCLOOXYGENASE INHIBITORS MERCK FROSST CANADA INC. (CA) 1997-10-09 WO disclosed