SCHEMBL7566367

SCHEMBL7566367

CSc1ccc(/C=C/c2cccc(F)c2)cc1

nearest known ligand 0.67

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 11/20 0.67
CYP1A1 P04798 6/20 0.61
CYP1A2 P05177 6/20 0.61
CYP1B1 Q16678 6/20 0.61
RELA Q04206 1/20 0.60
PTGS1 P23219 3/20 0.54
NQO2 P16083 1/20 0.54
PTGS2 P35354 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7566377 1.00 NFE2L2 (0.67) NFE2L2CYP1A1CYP1A2CYP1B1RELA
SCHEMBL3233599 0.86 NFE2L2 (0.48) NFE2L2CYP1A1CYP1A2CYP1B1RELA
SCHEMBL9849735 0.84 NFE2L2 (0.91) NFE2L2CYP1A2RELAPTGS1NQO2
SCHEMBL7569362 0.83 CYP1A1 (0.58) CYP1A1CYP1A2CYP1B1PTGS1PTGS2
SCHEMBL7569369 0.83 CYP1A1 (0.58) CYP1A1CYP1A2CYP1B1PTGS1PTGS2
SCHEMBL698584 0.81 NFE2L2 (1.00) NFE2L2CYP1A2RELAPTGS1NQO2
SCHEMBL7568993 0.81 CYP1A1 (0.59) NFE2L2CYP1A1CYP1A2CYP1B1PTGS1
SCHEMBL698583 0.81 NFE2L2 (1.00) NFE2L2CYP1A2RELAPTGS1NQO2
SCHEMBL7568987 0.81 CYP1A1 (0.59) NFE2L2CYP1A1CYP1A2CYP1B1PTGS1
SCHEMBL31317689 0.80 NFE2L2 (1.00) NFE2L2CYP1A2RELAPTGS1NQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0889878-B1 BISARYLCYCLOBUTENE DERIVATES AS CYCLOOXYGENASE INHIBITORS MERCK FROSST CANADA INC (CA) 2002-09-04 EP disclosed
EP-0889878-A1 BISARYLCYCLOBUTENE DERIVATES AS CYCLOOXYGENASE INHIBITORS MERCK FROSST CANADA INC. (CA) 1999-01-13 EP disclosed
US-5817700-A ANTIINFLAMMATORY AGENTS MERCK FROSST CANADA, INC. (CA) 1998-10-06 US disclosed
WO-1997036863-A1 BISARYLCYCLOBUTENE DERIVATES AS CYCLOOXYGENASE INHIBITORS MERCK FROSST CANADA INC. (CA) 1997-10-09 WO disclosed