Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.79 |
| ▸ | BRAF | P15056 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | CCR2 | P41597 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594332 | 0.88 | ALDH1A1 (0.71) | PKMBRAFALDH1A1NPC1MEN1 | |
| SCHEMBL9930374 | 0.82 | CCR2 (0.79) | PKMBRAFCCR2MEN1KMT2A | |
| SCHEMBL9930692 | 0.80 | CCR2 (0.78) | PKMBRAFCCR2MEN1KMT2A | |
| SCHEMBL9931149 | 0.80 | CCR2 (0.70) | PKMBRAFCCR2MEN1KMT2A | |
| SCHEMBL15009888 | 0.80 | ALDH1A1 (0.61) | PKMBRAFALDH1A1NPC1MEN1 | |
| SCHEMBL10878905 | 0.80 | ALDH1A1 (0.61) | PKMBRAFALDH1A1NPC1MEN1 | |
| SCHEMBL7578803 | 0.80 | TP53 (0.73) | PKMBRAFALDH1A1NPC1CCR2 | |
| SCHEMBL7578741 | 0.80 | BRAF (0.68) | PKMBRAFALDH1A1NPC1MEN1 | |
| SCHEMBL9930439 | 0.78 | CCR2 (0.71) | PKMBRAFCCR2MEN1KMT2A | |
| SCHEMBL7592227 | 0.78 | CCR2 (0.67) | BRAFCCR2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |