⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5684978 | 0.79 | ALDH1A1 (0.31) | — | |
| SCHEMBL9501121 | 0.73 | LMNA (0.36) | — | |
| SCHEMBL3860166 | 0.70 | — | — | |
| SCHEMBL5684885 | 0.69 | PREP (0.36) | — | |
| SCHEMBL3868121 | 0.69 | PSMB5 (0.32) | — | |
| SCHEMBL3866944 | 0.68 | PSMB5 (0.31) | — | |
| SCHEMBL3863801 | 0.68 | PSMB5 (0.31) | — | |
| SCHEMBL3866948 | 0.68 | PSMB5 (0.31) | — | |
| SCHEMBL3863806 | 0.68 | PSMB5 (0.31) | — | |
| SCHEMBL3869829 | 0.68 | PSMB5 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1240171-A1 | CYCLOPENTENEONE DERIVATIVES | Charterhouse Therapeutics Ltd. (GB) | 2002-09-18 | — | — | EP | disclosed |
| US-6452039-B1 | PROSTANOIC ACID DERIVATIVE WHEREIN THE ALPHA CHAIN HAS EIGHT OR MORE SKELETAL CARBON ATOMS; EXTREMELY STRONG ACTION; HYPERTENSION, ASTHMA, DIABETES, ARTERIAL SCLEROSIS, RENAL FAILURE, CARDIAC INFARCTION, ANGINA PECTORIS | SUCAMPO AG (CH) | 2002-09-17 | — | — | US | disclosed |
| EP-0857718-B1 | ENDOTHELIN ANTAGONIST | SUCAMPO AG (CH) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001044254-A1 | CYCLOPENTENEONE DERIVATIVES | CHARTERHOUSE THERAPEUTICS LTD. (GB) | 2001-06-21 | — | — | WO | disclosed |
| US-6242485-B1 | ADMINISTERING PROSTANOIC ACID DERIVATIVE TO TREAT VISION, KIDNEY, CARDIOVASCULAR AND BRAIN DISORDERS; HYPOTENSIVE AND ANTIASTHMATIC AGENTS | R-TECH UENO (JP) | 2001-06-05 | — | — | US | disclosed |
| EP-1042283-A1 | $g(v)-CYCLOALKYL-PROSTAGLANDIN E 2? DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033794-A1 | φ-CYCLOALKYL-PROSTAGLANDIN E2 DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-07-08 | — | — | WO | disclosed |
| EP-0857718-A1 | ENDOTHELIN ANTAGONIST | R-Tech Ueno, Ltd. (JP) | 1998-08-12 | — | — | EP | disclosed |
| WO-1992004339-A1 | NOVEL PROSTAGLANDIN I2 DERIVATIVES | ASAHI GLASS COMPANY LTD. (JP) | 1992-03-19 | — | — | WO | disclosed |
| EP-0308135-A2 | Ocular hypotensive agents | R-TECH UENO LTD. (JP) | 1989-03-22 | — | — | EP | disclosed |