Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946847 | 0.91 | TSHR (0.43) | TSHRALDH1A1DNM1 | |
| SCHEMBL5165999 | 0.86 | TSHR (0.39) | TSHRALDH1A1SMN1; SMN2DNM1 | |
| SCHEMBL6836259 | 0.83 | TSHR (0.36) | TSHRALDH1A1SMN1; SMN2DNM1 | |
| SCHEMBL7075066 | 0.81 | TSHR (0.34) | TSHRALDH1A1DNM1 | |
| SCHEMBL7075028 | 0.79 | ALDH1A1 (0.30) | TSHRALDH1A1 | |
| SCHEMBL7075538 | 0.78 | TSHR (0.32) | TSHRALDH1A1DNM1 | |
| SCHEMBL7077244 | 0.78 | TSHR (0.32) | TSHRALDH1A1 | |
| SCHEMBL11049161 | 0.78 | TSHR (0.32) | TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL7040570 | 0.78 | TSHR (0.32) | TSHRALDH1A1DNM1 | |
| SCHEMBL10772156 | 0.77 | DNM1 (0.43) | TSHRALDH1A1SMN1; SMN2DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996563-B1 | HETEROBICYCLIC SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DIABETES | HOFFMANN LA ROCHE (CH) | 2012-03-21 | — | — | EP | disclosed |
| US-8030308-B2 | Bicyclic sulfonamide derivatives which are L-CPT 1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2011-10-04 | — | — | US | disclosed |
| US-20110046112-A1 | NOVEL BICYCLIC SULFONAMIDE DERIVATIVES WHICH ARE L-CPT1 INHIBITORS | ACKERMANN JEAN | 2011-02-24 | — | — | US | disclosed |
| US-7879845-B2 | Liver carnitine-dependent palmitoyltransferase (L-CPT1) inhibitors such as 4-{[4-(5-Chloro-2-methoxy-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbonyl]-amino}-benzoic acid, used for the treatment of non-insulin dependent diabetes; antidiabetic agents | HOFFMANN-LA ROCHE INC. (US) | 2011-02-01 | — | — | US | disclosed |
| US-20100130484-A1 | NOVEL BICYCLIC SULFONAMIDE DERIVATIVES WHICH ARE L-CPT1 INHIBITORS | ACKERMANN JEAN | 2010-05-27 | — | — | US | disclosed |
| US-7696200-B2 | Bicyclic sulfonamide derivatives which are L-CPT1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2010-04-13 | — | — | US | disclosed |
| US-7527902-B2 | Photoreceptor layer having solid and liquid lubricants | XEROX CORPORATION (US) | 2009-05-05 | — | — | US | disclosed |
| US-20070191603-A1 | Novel bicyclic sulfonamide derivatives which are L-CPT1 inhibitors | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-08-16 | — | — | US | disclosed |
| US-20070026330-A1 | Photoreceptor layer having solid and liquid lubricants | XEROX CORPORATION | 2007-02-01 | — | — | US | disclosed |
| WO-2003064384-A2 | ENVIRONMENT FRIENDLY REAGENTS AND PROCESS FOR TRIFLUOROMETHYLSULFINYLATION OF ORGANIC COMPOUNDS | VIRBAC S.A. (FR) | 2003-08-07 | — | — | WO | disclosed |
| US-5954943-A | TREATING INTERIOR SURFACE OF FURNACE WITH SULFUR AND PHOSPHORUS COMPOUNDS TO FORM PASSIVATING PROTECTIVE COATING PRIOR TO INTRODUCING HYDROCARBON FEEDSTOCK AND STEAM FOR PYROLYSIS | NALCO/EXXON ENERGY CHEMICALS, L.P. (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0773778-B1 | HAIR STYLING COMPOSITION AND METHOD | UNILEVER PLC (GB) | 1999-03-31 | — | — | EP | disclosed |
| US-5656265-A | Hair styling composition and method | CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. (US) | 1997-08-12 | — | — | US | disclosed |
| EP-0773778-A1 | HAIR STYLING COMPOSITION AND METHOD | UNILEVER PLC (GB) | 1997-05-21 | — | — | EP | disclosed |
| US-5605796-A | REDUCING SIDE REACTION BY COMPLEXING WITH ENZYME WHICH DEGRADES COPIES | BEHRINGWERKE AG (DE) | 1997-02-25 | — | — | US | disclosed |
| WO-1996003966-A1 | HAIR STYLING COMPOSITION AND METHOD | UNILEVER PLC (GB) | 1996-02-15 | — | — | WO | disclosed |
| WO-1996002672-A1 | METHOD FOR PREVENTING AMPLIFICATION OF NUCLEIC ACID CONTAMINANTS IN AMPLIFICATION MIXTURES | BEHRINGWERKE AKTIENGESELLSCHAFT (DE) | 1996-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046112-A1 | NOVEL BICYCLIC SULFONAMIDE DERIVATIVES WHICH ARE L-CPT1 INHIBITORS | CPT1A, CPT1B, CPT2 | TSHR 2480/4885ALDH1A1 324/4885SMN1; SMN2 2801/4885 |
| US-20100130484-A1 | NOVEL BICYCLIC SULFONAMIDE DERIVATIVES WHICH ARE L-CPT1 INHIBITORS | CPT1A, CPT1B, CPT2 | TSHR 2480/4885ALDH1A1 324/4885SMN1; SMN2 2801/4885 |
| US-20070191603-A1 | Novel bicyclic sulfonamide derivatives which are L-CPT1 inhibitors | CPT1A, CPT1B, CPT2 | TSHR 2480/4885ALDH1A1 324/4885SMN1; SMN2 2801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.