Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5381405 | 0.89 | — | — | |
| Ethylene SCHEMBL7563790 | 0.83 | MCL1 (0.33) | MCL1 | |
| Cyclohexane SCHEMBL7563233 | 0.81 | EPHX1 (0.37) | MCL1 | |
| Ethylenediamine SCHEMBL11822541 | 0.79 | KMT2A (0.38) | MCL1MEN1KMT2A | |
| SCHEMBL27746025 | 0.76 | — | — | |
| Piperazine SCHEMBL8415291 | 0.75 | — | — | |
| SCHEMBL21315460 | 0.70 | — | — | |
| SCHEMBL24099446 | 0.67 | CPB2 (0.36) | MCL1KMT2A | |
| SCHEMBL11318032 | 0.67 | DPP7 (0.34) | MCL1MEN1KMT2A | |
| SCHEMBL10766041 | 0.67 | DPP7 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934256-B1 | PROCESS FOR THE PRODUCTION OF CYANOCINNAMAMIDES | HONEYWELL INT INC (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-0934256-A1 | PROCESS FOR THE PRODUCTION OF CYANOCINNAMAMIDES | AlliedSignal Inc. (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998016501-A1 | PROCESS FOR THE PRODUCTION OF CYANOCINNAMAMIDES | ALLIEDSIGNAL INC. (US) | 1998-04-23 | — | — | WO | disclosed |
| US-5654465-A | Process for the production of cyanocinnamamides | ALLIEDSIGNAL INC. (US) | 1997-08-05 | — | — | US | disclosed |