Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5381405 | 0.84 | — | — | |
| Cyclohexane SCHEMBL7563233 | 0.82 | EPHX1 (0.37) | — | |
| Ethylene SCHEMBL7563790 | 0.79 | MCL1 (0.33) | — | |
| Ethylenediamine SCHEMBL7570859 | 0.75 | MCL1 (0.36) | — | |
| SCHEMBL27746025 | 0.72 | — | — | |
| Piperazine SCHEMBL31087101 | 0.70 | ACHE (0.50) | — | |
| Piperazine SCHEMBL1613092 | 0.69 | MAPT (0.50) | — | |
| Piperazine SCHEMBL4778411 | 0.69 | MAPT (0.50) | — | |
| Piperazine SCHEMBL11438673 | 0.69 | MAPT (0.35) | — | |
| Piperazine SCHEMBL29112743 | 0.69 | KDM4E (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934256-A1 | PROCESS FOR THE PRODUCTION OF CYANOCINNAMAMIDES | AlliedSignal Inc. (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998016501-A1 | PROCESS FOR THE PRODUCTION OF CYANOCINNAMAMIDES | ALLIEDSIGNAL INC. (US) | 1998-04-23 | — | — | WO | disclosed |
| US-5654465-A | Process for the production of cyanocinnamamides | ALLIEDSIGNAL INC. (US) | 1997-08-05 | — | — | US | disclosed |