⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL505542 | 0.75 | — | — | |
| SCHEMBL29388695 | 0.75 | — | — | |
| SCHEMBL30477974 | 0.72 | — | — | |
| Fluoride SCHEMBL27636515 | 0.72 | DGAT1 (0.46) | — | |
| SCHEMBL2347585 | 0.72 | DGAT1 (0.46) | — | |
| SCHEMBL2458022 | 0.72 | — | — | |
| SCHEMBL321812 | 0.72 | — | — | |
| SCHEMBL5078535 | 0.70 | ALOX15 (0.46) | — | |
| SCHEMBL3606294 | 0.70 | — | — | |
| SCHEMBL18009875 | 0.70 | ALOX15 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1244531-C | Process for producing 5-bromo-2-fluorobenzoic boric acid | AMERICAN CYANAMID CO (US) | 2006-03-08 | — | — | CN | claimed |
| CN-1403430-A | Process for producing 5-bromo-2-fluorobenzoic boric acid | AMERICAN CYANAMID CO (US) | 2003-03-19 | — | — | CN | claimed |
| EP-0812847-B1 | Process for the preparation of 5-bromo-2-fluorobenzeneboronic acid | BASF AG (DE) | 2002-09-25 | — | — | EP | claimed |
| CN-1087743-C | Method for preparing 5-bromo-2-fluorobenzeneboronic acid | AMERICAN CYANAMID CO (US) | 2002-07-17 | — | — | CN | claimed |
| US-6198008-B1 | PREPARATION OF 5-BROMO-2-FLUOROBENZENEBORONIC ACID, USEFUL AS INTERMEDIATE IN PREPARATION OF FLUOROOLEFIN NON-ESTER PYRETHROID PESTICIDE, WHICH AVOIDS USE OF 2,4-DIBROMOFLUOROBENZENE | AMERICAN CYANAMID COMPANY | 2001-03-06 | — | — | US | claimed |
| US-5962742-A | Process for the preparation of 5-bromo-2 fluorobenzeneboronic acid | AMERICAN CYANAMID COMPANY (US) | 1999-10-05 | — | — | US | claimed |
| CN-1168887-A | Method for preparing 5-bromo-2-fluorobenzeneboronic acid | AMERICAN CYANAMID CO (US) | 1997-12-31 | — | — | CN | claimed |
| EP-0812847-A1 | Process for the preparation of 5-bromo-2-fluorobenzeneboronic acid | AMERICAN CYANAMID COMPANY (US) | 1997-12-17 | — | — | EP | claimed |
| JP-10059980-A | — | — | None | — | — | JP | disclosed |
| US-9198917-B2 | Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2015-12-01 | — | — | US | disclosed |
| EP-2931731-A1 | HEXAHYDROPYRANO [3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS AS INHIBITORS OF BACE1 | Pfizer Inc. (US) | 2015-10-21 | — | — | EP | disclosed |
| US-20150231144-A1 | Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER INC. (US) | 2015-08-20 | — | — | US | disclosed |
| US-9045498-B2 | Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2015-06-02 | — | — | US | disclosed |
| US-20140323474-A1 | Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER (US) | 2014-10-30 | — | — | US | disclosed |
| CN-1087743-C | Method for preparing 5-bromo-2-fluorobenzeneboronic acid | AMERICAN CYANAMID CO (US) | 2002-07-17 | — | — | CN | disclosed |
| US-6198008-B1 | PREPARATION OF 5-BROMO-2-FLUOROBENZENEBORONIC ACID, USEFUL AS INTERMEDIATE IN PREPARATION OF FLUOROOLEFIN NON-ESTER PYRETHROID PESTICIDE, WHICH AVOIDS USE OF 2,4-DIBROMOFLUOROBENZENE | AMERICAN CYANAMID COMPANY | 2001-03-06 | — | — | US | disclosed |
| US-5962742-A | Process for the preparation of 5-bromo-2 fluorobenzeneboronic acid | AMERICAN CYANAMID COMPANY (US) | 1999-10-05 | — | — | US | disclosed |
| JP-H1059980-A | PRODUCTION OF 5-BROMO-2-FLUOROBENZENEBORIC ACID | AMERICAN CYANAMID CO | 1998-03-03 | — | — | JP | disclosed |
| CN-1168887-A | Method for preparing 5-bromo-2-fluorobenzeneboronic acid | AMERICAN CYANAMID CO (US) | 1997-12-31 | — | — | CN | disclosed |
| EP-0812847-A1 | Process for the preparation of 5-bromo-2-fluorobenzeneboronic acid | AMERICAN CYANAMID COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |