Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589744 | 0.88 | MAPT (0.42) | KCNH2SCN9ACYP19A1KDM4EALDH1A1 | |
| SCHEMBL5372403 | 0.86 | MAPT (0.42) | KCNH2SCN9ACYP19A1PDE4APDE4B | |
| SCHEMBL5376626 | 0.85 | ALDH1A1 (0.49) | CYP19A1KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL5379428 | 0.85 | RAB9A (0.46) | KCNH2SCN9AKDM4EALDH1A1NPC1 | |
| SCHEMBL5376653 | 0.83 | RAB9A (0.44) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL5372050 | 0.82 | RAB9A (0.46) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL5376645 | 0.82 | RAB9A (0.45) | CYP19A1KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL5383106 | 0.82 | FFAR1 (0.47) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL5379384 | 0.81 | ALDH1A1 (0.67) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL5377119 | 0.81 | ALDH1A1 (0.45) | KDM4EALDH1A1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |