Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 18/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571588 | 0.89 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL7656222 | 0.88 | P2RX7 (0.81) | P2RX7 | |
| SCHEMBL7660207 | 0.87 | P2RX7 (0.77) | P2RX7 | |
| SCHEMBL7571529 | 0.83 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL7571526 | 0.83 | P2RX7 (0.70) | P2RX7 | |
| SCHEMBL6574267 | 0.80 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL7660582 | 0.79 | P2RX7 (0.84) | P2RX7 | |
| SCHEMBL4881070 | 0.79 | P2RX7 (0.79) | P2RX7 | |
| SCHEMBL4130035 | 0.79 | P2RX7 (0.77) | P2RX7 | |
| SCHEMBL4129828 | 0.79 | P2RX7 (0.77) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | claimed |
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | disclosed |