Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 15/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2709199 | 0.91 | P2RX7 (0.70) | P2RX7 | |
| SCHEMBL7571523 | 0.83 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL19428658 | 0.82 | L3MBTL1 (0.62) | NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL7656222 | 0.82 | P2RX7 (0.81) | P2RX7 | |
| SCHEMBL7660207 | 0.81 | P2RX7 (0.77) | P2RX7 | |
| SCHEMBL7656113 | 0.79 | P2RX7 (0.70) | P2RX7 | |
| SCHEMBL7571529 | 0.77 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL7455062 | 0.77 | SMN1; SMN2 (0.55) | P2RX7TP53MAPT | |
| SCHEMBL7571536 | 0.77 | P2RX7 (0.70) | P2RX7 | |
| SCHEMBL7571757 | 0.76 | MEN1 (0.53) | P2RX7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | claimed |
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | disclosed |