Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.80 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | USP8 | P40818 | 4/20 | 0.56 |
| ▸ | USP2 | O75604 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25140636 | 0.84 | SMN1; SMN2 (0.70) | SMN1; SMN2TP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL9931194 | 0.82 | CCR2 (0.72) | SMN1; SMN2TP53KMT2AMEN1CCR2 | |
| SCHEMBL18104339 | 0.81 | KMT2A (0.76) | SMN1; SMN2TP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL9930906 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2TP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL9930912 | 0.81 | SMN1; SMN2 (0.71) | SMN1; SMN2TP53ALDH1A1MAPTCCR2 | |
| SCHEMBL15009446 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2TP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL15009604 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2TP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL9931071 | 0.80 | CCR2 (0.68) | SMN1; SMN2TP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL16747602 | 0.80 | CCR2 (0.61) | SMN1; SMN2TP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL7573848 | 0.80 | ALDH1A1 (0.60) | SMN1; SMN2TP53ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |