Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27489867 | 0.87 | IKBKB (0.53) | ALDH1A1RAD52KDM4EUHRF1 | |
| SCHEMBL13425642 | 0.84 | RAD52 (0.48) | ALDH1A1RAB9ARAD52KDM4EMEN1 | |
| SCHEMBL27624951 | 0.82 | IKBKB (0.54) | ALDH1A1NPC1RAB9ARAD52KDM4E | |
| SCHEMBL7564771 | 0.82 | RAD52 (0.59) | ALDH1A1NPC1RAB9ARAD52KDM4E | |
| SCHEMBL7564788 | 0.82 | KDM4E (0.47) | ALDH1A1KDM4EMEN1KMT2AGLA | |
| SCHEMBL4903727 | 0.82 | ALDH1A1 (0.54) | ALDH1A1NPC1RAB9ARAD52KDM4E | |
| SCHEMBL8520765 | 0.82 | ALDH1A1 (0.49) | ALDH1A1NPC1RAB9ARAD52KDM4E | |
| SCHEMBL30543767 | 0.80 | TDP1 (0.50) | ALDH1A1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL11981379 | 0.80 | TDP1 (0.50) | ALDH1A1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL7567602 | 0.79 | ALDH1A1 (0.61) | ALDH1A1KDM4EPDE10ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1116285-C | Bis(acridinecarboxamide) and Bis(phenazinecarboxamide) as antitumour agents | XENOVA LTD (GB) | 2003-07-30 | — | — | CN | disclosed |
| EP-0934278-B1 | BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS | XENOVA LTD (GB) | 2002-09-04 | — | — | EP | disclosed |
| US-6114332-A | BACTERICIDES | XENOVA LIMITED (GB) | 2000-09-05 | — | — | US | disclosed |
| CN-1240430-A | Bis(acridinecarboxamide) and Bis(phenazinecarboxamide) as antitumour agents | XENOVA LTD (GB) | 2000-01-05 | — | — | CN | disclosed |
| EP-0934278-A1 | BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS | XENOVA LIMITED (GB) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017650-A1 | BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS | XENOVA LIMITED (GB) | 1998-04-30 | — | — | WO | disclosed |