Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7565443 | 0.87 | PTPN2 (0.38) | PTPN1ALDH1A1KEAP1CYP1A2CYP2C9 | |
| SCHEMBL7564859 | 0.86 | PARP1 (0.37) | PTPN1MEN1KMT2A | |
| SCHEMBL5839246 | 0.83 | PTPN1 (0.46) | PTPN1 | |
| SCHEMBL5843765 | 0.80 | ALDH1A1 (0.38) | ALDH1A1KEAP1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7155796 | 0.77 | PTPN2 (0.43) | PTPN1ALDH1A1KEAP1CYP1A2CYP2C9 | |
| SCHEMBL5837672 | 0.73 | PTPN1 (0.50) | PTPN1 | |
| SCHEMBL7564276 | 0.72 | CYP1A2 (0.39) | ALDH1A1CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL5837045 | 0.72 | PTPN1 (0.52) | PTPN1 | |
| SCHEMBL7557647 | 0.72 | PTPN1 (0.37) | PTPN1ALDH1A1KDM4EMEN1GAA | |
| SCHEMBL5810837 | 0.71 | RAB9A (0.51) | PTPN1ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214060-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017516-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2001-03-15 | — | — | WO | disclosed |