Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.63 |
| ▸ | LMNA | P02545 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.62 |
| ▸ | RELA | Q04206 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 5/20 | 0.58 |
| ▸ | RECQL | P46063 | 3/20 | 0.58 |
| ▸ | CRHBP | P24387 | 1/20 | 0.57 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.57 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9967877 | 0.92 | PTGES2 (0.65) | PTGES2ALDH1A1MCOLN3KMT2ALMNA | |
| SCHEMBL7573985 | 0.91 | PTGES2 (0.68) | PTGES2ALDH1A1MCOLN3KMT2ALMNA | |
| SCHEMBL7571625 | 0.89 | PTGES2 (0.65) | PTGES2ALDH1A1MCOLN3KMT2ALMNA | |
| SCHEMBL7569588 | 0.89 | PTGES2 (0.69) | PTGES2ALDH1A1MCOLN3KMT2ALMNA | |
| SCHEMBL16747580 | 0.87 | LMNA (0.63) | PTGES2ALDH1A1MCOLN3KMT2ALMNA | |
| SCHEMBL9967982 | 0.87 | MEN1 (0.62) | PTGES2ALDH1A1MCOLN3KMT2ALMNA | |
| SCHEMBL7573153 | 0.86 | PTGES2 (0.62) | PTGES2ALDH1A1MCOLN3KMT2ALMNA | |
| SCHEMBL3782564 | 0.86 | PTGES2 (1.00) | PTGES2ALDH1A1MCOLN3KMT2ALMNA | |
| SCHEMBL7572156 | 0.86 | NFKBIA (0.64) | PTGES2ALDH1A1MCOLN3KMT2ALMNA | |
| SCHEMBL15821860 | 0.85 | MEN1 (0.74) | PTGES2ALDH1A1MCOLN3KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |