Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKBIA | P25963 | 2/20 | 0.64 |
| ▸ | RELA | Q04206 | 2/20 | 0.64 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7573029 | 0.86 | PTGES2 (0.74) | NFKBIARELAPTGES2RECQLMCOLN3 | |
| SCHEMBL7591204 | 0.85 | NFKBIA (0.57) | NFKBIARELAPTGES2RECQLMCOLN3 | |
| SCHEMBL17737449 | 0.84 | NFKBIA (0.62) | NFKBIARELAPTGES2MCOLN3ALDH1A1 | |
| SCHEMBL7573153 | 0.83 | PTGES2 (0.62) | NFKBIARELAPTGES2RECQLMCOLN3 | |
| SCHEMBL11973892 | 0.82 | THRB (0.65) | NFKBIARELARECQLALDH1A1MEN1 | |
| SCHEMBL7573985 | 0.81 | PTGES2 (0.68) | NFKBIARELAPTGES2RECQLMCOLN3 | |
| SCHEMBL3981083 | 0.80 | METAP2 (0.64) | NFKBIARELAPTGES2RECQLMCOLN3 | |
| SCHEMBL7571625 | 0.79 | PTGES2 (0.65) | NFKBIARELAPTGES2RECQLMCOLN3 | |
| SCHEMBL9967877 | 0.79 | PTGES2 (0.65) | NFKBIARELAPTGES2RECQLMCOLN3 | |
| SCHEMBL7569588 | 0.79 | PTGES2 (0.69) | NFKBIARELAPTGES2RECQLMCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |