SCHEMBL7573255

SCHEMBL7573255

CS(=O)(=O)Cc1c(C(=O)c2cnoc2C2CC2)ccc(Cl)c1Br

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.32
NR1H4 Q96RI1 4/20 0.31
PDE2A O00408 1/20 0.30
HSD17B13 Q7Z5P4 1/20 0.30
GAA P10253 1/20 0.30
FABP1 P07148 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7575598 0.89 DHODH (0.33) DHODHNR1H4PDE2AFABP1MEN1
SCHEMBL9117026 0.89 DHODH (0.33) DHODHPDE2A
SCHEMBL7577830 0.88 DHODH (0.32) DHODHNR1H4PDE2AMEN1KMT2A
SCHEMBL7575354 0.87 DHODH (0.35) DHODHNR1H4PDE2AMEN1KMT2A
SCHEMBL7576312 0.84 DHODH (0.32) DHODHPDE2AMEN1KMT2A
SCHEMBL7574755 0.84 DHODH (0.33) DHODHNR1H4PDE2A
SCHEMBL9116308 0.84 DHODH (0.33) DHODHPDE2AMEN1KMT2A
SCHEMBL7572977 0.84 PDE4D (0.35) DHODHNR1H4
SCHEMBL7577500 0.83 PDE2A (0.32) DHODHPDE2AMEN1KMT2A
SCHEMBL7574569 0.83 DHODH (0.32) DHODHPDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0609798-B1 4-Benzoyl isoxazoles and their use as herbicides AVENTIS AGRICULTURE LTD (GB) 2002-10-02 EP claimed
EP-0609798-A1 4-Benzoyl isoxazoles and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-08-10 EP claimed
EP-0609798-B1 4-Benzoyl isoxazoles and their use as herbicides AVENTIS AGRICULTURE LTD (GB) 2002-10-02 EP disclosed
US-5374606-A Pre- and postemergence RHONE-POULENC AGRICULTURE LIMITED (GB) 1994-12-20 US disclosed
EP-0609798-A1 4-Benzoyl isoxazoles and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-08-10 EP disclosed