Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 19/20 | 0.73 |
| ▸ | DRD2 | P14416 | 11/20 | 0.73 |
| ▸ | HTR2A | P28223 | 11/20 | 0.52 |
| ▸ | HTR2C | P28335 | 11/20 | 0.52 |
| ▸ | HTR2B | P41595 | 11/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6841222 | 0.95 | SIGMAR1 (0.80) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6836351 | 0.92 | SIGMAR1 (0.69) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6836333 | 0.88 | SIGMAR1 (0.88) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6840820 | 0.85 | SIGMAR1 (0.93) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6840764 | 0.84 | SIGMAR1 (1.00) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9375055 | 0.77 | SIGMAR1 (1.00) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL9376355 | 0.76 | SIGMAR1 (1.00) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6841426 | 0.76 | SIGMAR1 (0.68) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL15692839 | 0.73 | ALDH1A1 (0.54) | SIGMAR1HTR2AHTR2CHTR2BADRA1D | |
| SCHEMBL9374117 | 0.73 | SIGMAR1 (1.00) | SIGMAR1DRD2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235808-A2 | TRICYCLIC ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| WO-2000075116-A2 | TRICYCLIC ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2000-12-14 | — | — | WO | claimed |