SCHEMBL7573423

SCHEMBL7573423

CCS(=O)(=O)Cc1c(C(=O)c2cnoc2C2CC2)ccc(Cl)c1Cl

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.32
SLC6A9 P48067 4/20 0.32
PDE2A O00408 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
NR1H4 Q96RI1 1/20 0.30
MAPK14 Q16539 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9114823 0.93 SLC6A9 (0.33) DHODHSLC6A9PDE2ANR1H4
SCHEMBL7575598 0.90 DHODH (0.33) DHODHSLC6A9PDE2AMEN1KMT2A
SCHEMBL7573706 0.83 DHODH (0.32) DHODHPDE2AMEN1KMT2A
SCHEMBL7575595 0.83 DHODH (0.33) DHODHPDE2AMEN1KMT2A
SCHEMBL7573986 0.82 PDE2A (0.33) DHODHPDE2AMEN1KMT2A
SCHEMBL7575354 0.82 DHODH (0.35) DHODHSLC6A9PDE2AMEN1KMT2A
SCHEMBL9117414 0.81 DHODH (0.32) DHODHPDE2AMAPK14
SCHEMBL7575680 0.81 NAMPT (0.32) DHODHPDE2A
SCHEMBL9114607 0.81 DHODH (0.33) DHODHMEN1KMT2A
SCHEMBL8491541 0.80 DHODH (0.41) DHODHPDE2AMEN1KMT2AMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0609798-B1 4-Benzoyl isoxazoles and their use as herbicides AVENTIS AGRICULTURE LTD (GB) 2002-10-02 EP claimed
EP-0609798-A1 4-Benzoyl isoxazoles and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-08-10 EP claimed
EP-0609798-B1 4-Benzoyl isoxazoles and their use as herbicides AVENTIS AGRICULTURE LTD (GB) 2002-10-02 EP disclosed
CN-1082790-C Herbicides RHONE POULENE AGRICULTURE LTD (GB) 2002-04-17 CN disclosed
EP-0625505-B1 2-Cyano-1,3-dione derivatives and their use as herbicides RHONE POULENC AGRICULTURE (GB) 1998-10-28 EP disclosed
US-5374606-A Pre- and postemergence RHONE-POULENC AGRICULTURE LIMITED (GB) 1994-12-20 US disclosed
EP-0625505-A2 2-Cyano-1,3-dione derivatives and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-11-23 EP disclosed
EP-0609798-A1 4-Benzoyl isoxazoles and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-08-10 EP disclosed