Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naproxen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 0.50 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CDC42 | P60953 | 1/20 | 0.50 |
| ▸ | RAC1 | P63000 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naproxen SCHEMBL7582595 | 1.00 | AKR1C3 (0.50) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL14190061 | 0.84 | PTGS2 (0.43) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL5140597 | 0.84 | PTGS2 (0.43) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL5494443 | 0.84 | PTGS2 (0.43) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Ibuprofen SCHEMBL7573168 | 0.82 | PTGS2 (0.48) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxcinod SCHEMBL29663794 | 0.82 | PTGS2 (0.57) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxcinod SCHEMBL1170879 | 0.82 | PTGS2 (0.57) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxcinod SCHEMBL1448284 | 0.82 | PTGS2 (0.57) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Flurbiprofen SCHEMBL7581730 | 0.81 | AKR1C3 (0.52) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL1245933 | 0.81 | PTGS2 (0.56) | AKR1C3AKR1C2PTGS2PTGS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002092072-A2 | DRUGS FOR THE TREATMENT OF THE ALZHEIMER DISEASE | NICOX S.A. (FR) | 2002-11-21 | — | — | WO | claimed |