Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15054272 | 0.88 | MAPK1 (0.45) | MAPTTP53MAPK1GAANPSR1 | |
| SCHEMBL10518080 | 0.87 | MEN1 (0.52) | MAPTTP53MAPK1GAANPSR1 | |
| SCHEMBL21050728 | 0.87 | MAPT (0.46) | MAPTTP53MAPK1GAANPSR1 | |
| SCHEMBL15055104 | 0.85 | GAA (0.46) | MAPTTP53MAPK1GAANPSR1 | |
| SCHEMBL15054971 | 0.85 | HSP90AA1 (0.43) | MAPTTP53MAPK1GAANPSR1 | |
| SCHEMBL11393991 | 0.85 | MAPT (0.48) | MAPTTP53MAPK1GAANPSR1 | |
| SCHEMBL2911498 | 0.85 | MEN1 (0.52) | MAPTTP53MAPK1GAANPSR1 | |
| SCHEMBL18530485 | 0.84 | KDM4E (0.44) | MAPTTP53MAPK1GAANPSR1 | |
| SCHEMBL8660777 | 0.82 | GABRP (0.41) | MAPTTP53MEN1KMT2ATHRB | |
| SCHEMBL529424 | 0.82 | MAPK1 (0.66) | MAPTTP53MAPK1GAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013096151-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2013-06-27 | — | — | WO | disclosed |
| EP-0876349-B1 | QUINOLINE DERIVATIVES AS GNRH ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-09-11 | — | — | EP | disclosed |
| US-6087503-A | ACID, ESTER OR AMIDE DERIVATIVES FOR CONTROL OF HORMONES ESPECIALLY IN HORMONE RELATED CANCER | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 2000-07-11 | — | — | US | disclosed |
| US-6015789-A | LUTEINIZING HORMONE RELEASING HORMONE AGONIST AND A LUTEINIZING HORMONE RELEASING HORMONE ANTAGONIST IN COMBINATION, | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-01-18 | — | — | US | disclosed |
| US-5977132-A | GALACTORRHEA, HYPERPROLACTINEMIC OVULATION, PROLACTINOMA AND BRAIN TUMORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0906115-A1 | COMBINED USE OF GnRH AGONIST AND ANTAGONIST | Takeda Chemical Industries, Ltd. (JP) | 1999-04-07 | — | — | EP | disclosed |
| CN-1200114-A | Quinoline derivatives as GNRH antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-11-25 | — | — | CN | disclosed |
| US-5807869-A | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-09-15 | — | — | US | disclosed |
| WO-1997040846-A1 | COMBINED USE OF GnRH AGONIST AND ANTAGONIST | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-11-06 | — | — | WO | disclosed |
| EP-0781774-A2 | Prolactin production inhibitory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-02 | — | — | EP | disclosed |