Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571843 | 0.88 | CFTR (0.54) | GAAPKMLMNAPOLBMEN1 | |
| SCHEMBL1823331 | 0.75 | CFTR (0.46) | GAAPKMLMNAPOLBMEN1 | |
| SCHEMBL19021292 | 0.74 | CFTR (0.73) | GAAPKMLMNAPOLBMEN1 | |
| SCHEMBL18161908 | 0.73 | LMNA (0.36) | GAAPKMLMNAPOLBMEN1 | |
| SCHEMBL7843306 | 0.72 | CFTR (0.46) | GAAPKMLMNAPOLBMEN1 | |
| SCHEMBL19010401 | 0.69 | CFTR (0.63) | GAAPKMLMNAPOLBMEN1 | |
| SCHEMBL10680943 | 0.67 | CFTR (0.41) | GAAPKMLMNAPOLBMEN1 | |
| SCHEMBL4261355 | 0.66 | NPSR1 (0.47) | GAAPKMLMNAMEN1MAPT | |
| SCHEMBL11249029 | 0.64 | CFTR (0.55) | GAAPKMLMNAPOLBMEN1 | |
| SCHEMBL7313184 | 0.63 | PDK2 (0.49) | LMNAMEN1MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448255-B1 | ELEVATE HDL CHOLESTEROL CONCENTRATION; MAY BE USEFUL FOR TREATMENT OF ATHEROSCLEROTIC CONDITIONS AND CORONARY HEART DISEASE | WYETH | 2002-09-10 | — | — | US | disclosed |
| US-20020061900-A1 | Imidazo-isoquinolin-5-one derivatives, pyrimido-isoquinolin-6-one derivatives and imidazo-naphthyridin-5-one derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020061900-A1 | Imidazo-isoquinolin-5-one derivatives, pyrimido-isoquinolin-6-one derivatives and imidazo-naphthyridin-5-one derivatives | PPARD, FABP3, FFAR3 | GAA 4776/4885PKM 3430/4885LMNA 983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.