Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9146594 | 0.91 | CYP19A1 (0.63) | METAP1CYP19A1ALDH1A1MAOBHTR2A | |
| SCHEMBL4422957 | 0.88 | ACHE (0.65) | METAP1CYP19A1ALOX15ALOX12ALDH1A1 | |
| SCHEMBL6286139 | 0.87 | CYP19A1 (0.55) | METAP1CYP19A1ALDH1A1CYP3A4MAOB | |
| SCHEMBL16013457 | 0.85 | METAP1 (0.51) | METAP1CYP19A1ALDH1A1ACHEHTR2A | |
| SCHEMBL6669546 | 0.85 | CYP24A1 (0.53) | METAP1CYP19A1ALOX15ALOX12HTR2A | |
| SCHEMBL22204650 | 0.85 | METAP1 (0.45) | METAP1CYP19A1ALOX15ALOX12ALDH1A1 | |
| SCHEMBL9148955 | 0.84 | CYP19A1 (0.59) | CYP19A1ALOX15ALOX12ALDH1A1MAP2K3 | |
| SCHEMBL13885522 | 0.82 | CYP24A1 (0.48) | METAP1CYP19A1ALOX15ALOX12ALDH1A1 | |
| SCHEMBL3654990 | 0.82 | CYP24A1 (0.48) | METAP1CYP19A1ALOX15ALOX12ALDH1A1 | |
| SCHEMBL29218130 | 0.81 | MAP2K3 (0.47) | CYP19A1ALOX15ALOX12ALDH1A1MAP2K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873992-B1 | Indene compounds having activity as SERMs | LILLY CO ELI (US) | 2002-09-25 | — | — | EP | disclosed |
| US-5994370-A | ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1998048806-A1 | INDENE COMPOUNDS HAVING ACTIVITY AS SERMS | ELI LILLY AND COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |
| EP-0873992-A1 | Indene compounds having activity as SERMs | ELI LILLY AND COMPANY (US) | 1998-10-28 | — | — | EP | disclosed |
| US-5021414-A | Antiestrogen | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-06-04 | — | — | US | disclosed |
| US-4904661-A | ANTIESTROGENS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-02-27 | — | — | US | disclosed |
| US-4732912-A | ANTIESTROGENS, ANTITUMOR AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-03-22 | — | — | US | disclosed |
| EP-0124369-B1 | PHENOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-06-24 | — | — | EP | disclosed |
| EP-0124369-A1 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-11-07 | — | — | EP | disclosed |