Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.77 |
| ▸ | ARG2 | P78540 | 4/20 | 0.48 |
| ▸ | ARG1 | P05089 | 3/20 | 0.48 |
| ▸ | NOS2 | P35228 | 6/20 | 0.47 |
| ▸ | NOS1 | P29475 | 4/20 | 0.47 |
| ▸ | NOS3 | P29474 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL31644218 | 0.88 | GSR (0.91) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL1042282 | 0.88 | GSR (0.91) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL31039861 | 0.88 | GSR (0.91) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL4641859 | 0.88 | GSR (0.91) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL5060018 | 0.88 | GSR (0.91) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL15286920 | 0.88 | GSR (0.91) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL12867528 | 0.88 | GSR (1.00) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL1645 | 0.88 | GSR (1.00) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL7343 | 0.88 | GSR (1.00) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL9439278 | 0.88 | GSR (1.00) | GSRARG2ARG1NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749452-B1 | POLYMER-CONJUGATED MALONIC ACID DERIVATIVES AND THEIR USE AS MEDICAMENTS AND DIAGNOSTIC AGENTS | GLYCOREX AB (SE) | 2002-07-17 | — | — | EP | claimed |
| US-6037467-A | Methods for preparing carbohydrate-containing hydrophilic polymers | GLYCOREX AB (SE) | 2000-03-14 | — | — | US | claimed |
| US-5817742-A | Polymer-conjugated malonic acid derivatives and their use as medicaments and diagnostic agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-10-06 | — | — | US | claimed |
| US-9719987-B2 | Immunoadsorbent compositions comprising hyaluronic acid oligosaccharides | FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL) (ES) | 2017-08-01 | — | — | US | disclosed |
| US-20150192576-A1 | METHODS AND REAGENTS FOR PREVENTION AND/OR TREATMENT OF TRANSPLANT REJECTION | FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL) (ES) | 2015-07-09 | — | — | US | disclosed |
| EP-2698636-A1 | Methods and reagents for prevention and/or treatment of transplant rejection | Fundació Institut d'Investigació Biomèdica de Bellvitge (ES) | 2014-02-19 | — | — | EP | disclosed |
| US-6406894-B1 | BIODEGRADABLE POLYMER, DISACCHARIDE OR OLIGOSACCHARIDE, CROSSLINKING AND COUPLING | GLYCOREX AB (SE) | 2002-06-18 | — | — | US | disclosed |
| US-6037467-A | Methods for preparing carbohydrate-containing hydrophilic polymers | GLYCOREX AB (SE) | 2000-03-14 | — | — | US | disclosed |
| US-5817742-A | Polymer-conjugated malonic acid derivatives and their use as medicaments and diagnostic agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-10-06 | — | — | US | disclosed |
| US-5470843-A | Carbohydrate-containing polymers, their preparation and use | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150192576-A1 | METHODS AND REAGENTS FOR PREVENTION AND/OR TREATMENT OF TRANSPLANT REJECTION | CD44, HLA-C, HAVCR2 | GSR 1877/4885ARG2 2975/4885ARG1 1149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.