SCHEMBL7573671

SCHEMBL7573671

[O]C(C(=O)OCc1ccccc1)c1ccccc1[N+](=O)[O-]

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.52
ALDH1A1 P00352 6/20 0.51
TSHR P16473 1/20 0.50
KMT2A Q03164 4/20 0.44
RAB9A P51151 3/20 0.44
MEN1 O00255 2/20 0.44
NPC1 O15118 2/20 0.44
SGMS2 Q8NHU3 1/20 0.43
MAPK1 P28482 2/20 0.42
MITF O75030 1/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
HTT P42858 1/20 0.42
CCR6 P51684 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
ITGA4 P13612 1/20 0.42
ITGB7 P26010 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
SLC6A2 P23975 1/20 0.41
SLC6A3 Q01959 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7062308 0.79 ALDH1A1 (0.48) CYP1A2ALDH1A1TSHRKMT2ARAB9A
SCHEMBL2706463 0.75 ALDH1A1 (0.61) ALDH1A1TSHRKMT2ARAB9AMEN1
SCHEMBL11145783 0.74 CYP1A2 (0.47) CYP1A2ALDH1A1TSHRKMT2ARAB9A
SCHEMBL19463040 0.74 ALDH1A1 (0.42) CYP1A2ALDH1A1TSHRKMT2ARAB9A
SCHEMBL9258822 0.73 TDP1 (0.55) ALDH1A1KMT2ARAB9ANPC1MAPK1
SCHEMBL10596245 0.73 ALDH1A1 (0.55) CYP1A2ALDH1A1TSHRKMT2AMAPK1
SCHEMBL3163836 0.73 ALDH1A1 (0.55) ALDH1A1KMT2ARAB9ANPC1MAPK1
SCHEMBL1338736 0.72 ALDH1A1 (0.50) CYP1A2ALDH1A1KMT2ARAB9AMEN1
SCHEMBL20126457 0.72 ALDH1A1 (0.58) ALDH1A1KMT2ARAB9AMEN1NPC1
SCHEMBL2704301 0.72 ALDH1A1 (0.51) ALDH1A1KMT2ARAB9AMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1228060-A1 ARYLALKANE, ARYLALKENE AND ARYL AZAALKANE, MEDICAMENTS CONTAINING SAID COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF Boehringer Ingelheim Pharma KG (DE) 2002-08-07 EP disclosed
EP-1163239-A1 MODIFIED AMINO-ACID AMIDES AS CGRP ANTAGONISTS Boehringer Ingelheim Pharma KG (DE) 2001-12-19 EP disclosed
WO-2001032649-A1 ARYLALKANE, ARYLALKENE AND ARYL AZAALKANE, MEDICAMENTS CONTAINING SAID COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA KG (DE) 2001-05-10 WO disclosed
WO-2000055154-A1 MODIFIED AMINO-ACID AMIDES AS CGRP ANTAGONISTS BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-09-21 WO disclosed