SCHEMBL7574010

SCHEMBL7574010

CCCOc1cccc(CO)c1I

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.41
CNR2 P34972 1/20 0.41
MCHR1 Q99705 1/20 0.40
CYP2A6 P11509 1/20 0.39
MAPT P10636 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
GAA P10253 1/20 0.38
HTR1B P28222 2/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
ATM Q13315 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
HTR1D P28221 1/20 0.36
TP53 P04637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7216512 0.82 MAPT (0.52) CNR1CNR2CYP2A6MAPTNPSR1
SCHEMBL26586938 0.81 KDM4E (0.37) CNR1CNR2MAPTNPSR1L3MBTL1
SCHEMBL16955136 0.81 PDCD1 (0.44) CNR1CNR2MCHR1CYP2A6MAPT
SCHEMBL1135286 0.79 PTPN1 (0.39) SLC6A2SLC6A4
SCHEMBL16962845 0.79 MAPT (0.42) CNR1CNR2MCHR1CYP2A6MAPT
SCHEMBL16959265 0.79 NPC1 (0.42) CNR1CNR2MCHR1CYP2A6MAPT
SCHEMBL16952926 0.79 MCHR1 (0.40) CNR1CNR2MCHR1CYP2A6MAPT
SCHEMBL16962193 0.79 MCHR1 (0.40) CNR1CNR2MCHR1CYP2A6MAPT
SCHEMBL1907925 0.78 PDE4A (0.44) MAPTL3MBTL1SLC6A2SLC6A4TP53
SCHEMBL16950723 0.78 L3MBTL1 (0.45) CNR1CNR2MCHR1CYP2A6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0817782-B1 PHENYL DERIVATIVES USEFUL AS ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2002-09-25 EP disclosed
US-6147111-A KIDNEY, BRAIN, AND CARDIOVASCULAR DISORDERS; VASODILATION SMITHKLINE BEECHAM P.L.C. (GB) 2000-11-14 US disclosed
EP-0817782-A1 PHENYL DERIVATIVES USEFUL AS ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1998-01-14 EP disclosed
WO-1996030358-A1 PHENYL DERIVATIVES USEFUL AS ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1996-10-03 WO disclosed