Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | GAA | P10253 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | UQCRB | P14927 | 1/20 | 0.65 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.65 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.65 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | CDK8 | P49336 | 1/20 | 0.60 |
| ▸ | NEK2 | P51955 | 1/20 | 0.60 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.60 |
| ▸ | DDX3X | O00571 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7589375 | 0.87 | MEN1 (0.77) | MEN1KMT2AGAATSHRKEAP1 | |
| SCHEMBL6296987 | 0.86 | GAA (0.93) | MEN1KMT2AGAAMAPTMAPK1 | |
| SCHEMBL7085112 | 0.86 | GAA (0.75) | MEN1KMT2AGAAMAPTMAPK1 | |
| SCHEMBL752345 | 0.85 | GAA (0.80) | MEN1KMT2AGAAMAPTMAPK1 | |
| SCHEMBL3259826 | 0.83 | GAA (1.00) | MEN1KMT2AGAAMAPTMAPK1 | |
| SCHEMBL6832818 | 0.83 | KMT2A (0.71) | MEN1KMT2AGAAMAPTMAPK1 | |
| SCHEMBL1348234 | 0.83 | LMNA (0.75) | MEN1KMT2AGAAMAPTMAPK1 | |
| SCHEMBL3260803 | 0.83 | GAA (0.71) | MEN1KMT2AGAAMAPTMAPK1 | |
| SCHEMBL7854392 | 0.82 | TSHR (0.70) | MEN1KMT2ATSHRKEAP1NFE2L2 | |
| SCHEMBL3188254 | 0.81 | GAA (0.69) | MEN1KMT2AGAAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |