Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.76 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.76 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | CDK8 | P49336 | 1/20 | 0.59 |
| ▸ | NEK2 | P51955 | 1/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7854392 | 0.90 | TSHR (0.70) | MEN1KMT2ATSHRKEAP1NFE2L2 | |
| SCHEMBL13875339 | 0.87 | ALDH1A1 (0.71) | MEN1KMT2ATSHRKEAP1NFE2L2 | |
| SCHEMBL6561655 | 0.87 | MEN1 (0.66) | MEN1KMT2ATSHRKEAP1NFE2L2 | |
| SCHEMBL7574096 | 0.87 | MEN1 (0.71) | MEN1KMT2ATSHRKEAP1NFE2L2 | |
| SCHEMBL30737629 | 0.87 | MEN1 (0.66) | MEN1KMT2ATSHRKEAP1NFE2L2 | |
| SCHEMBL7569823 | 0.85 | PTPN1 (0.67) | MEN1KMT2ATSHRKEAP1NFE2L2 | |
| SCHEMBL7578880 | 0.84 | KEAP1 (0.76) | MEN1KMT2ATSHRKEAP1NFE2L2 | |
| SCHEMBL3782482 | 0.84 | CA1 (0.74) | MEN1KMT2ATSHRKEAP1NFE2L2 | |
| SCHEMBL7571620 | 0.84 | POLB (0.68) | MEN1KMT2ATSHRKEAP1NFE2L2 | |
| SCHEMBL31681353 | 0.84 | FFAR4 (0.62) | MEN1KMT2ATSHRKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |
| EP-0991625-A2 | INHIBITORS OF FACTOR XA WITH A NEUTRAL P1 SPECIFICITY GROUP | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998057937-A2 | INHIBITORS OF FACTOR XA WITH A NEUTRAL P1 SPECIFICITY GROUP | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-12-23 | — | — | WO | disclosed |