Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.52 |
| ▸ | EBP | Q15125 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 3/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571727 | 0.99 | LTA4H (0.51) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL7576311 | 0.89 | ESR1 (0.61) | ESR1ESR2HRH3 | |
| SCHEMBL8504413 | 0.88 | EBP (0.64) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL7573077 | 0.88 | ESR1 (0.60) | ESR1ESR2HRH3 | |
| SCHEMBL7572321 | 0.87 | ESR1 (0.53) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL7572449 | 0.86 | ESR1 (0.52) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL8504438 | 0.84 | ESR1 (0.55) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL7573537 | 0.84 | ESR1 (0.53) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL7580940 | 0.84 | ESR1 (0.64) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL7580377 | 0.83 | ESR1 (0.51) | LTA4HEBPSIGMAR1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994370-A | ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 1999-11-30 | — | — | US | claimed |
| EP-0873992-B1 | Indene compounds having activity as SERMs | LILLY CO ELI (US) | 2002-09-25 | — | — | EP | disclosed |
| US-5994370-A | ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0873992-A1 | Indene compounds having activity as SERMs | ELI LILLY AND COMPANY (US) | 1998-10-28 | — | — | EP | disclosed |