Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 2/20 | 0.44 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13374857 | 0.97 | TMEM97 (0.49) | SIGMAR1TMEM97PARP1PREPAADAT | |
| SCHEMBL31603397 | 0.92 | PARP1 (0.49) | SIGMAR1TMEM97PARP1 | |
| SCHEMBL29097370 | 0.83 | TMEM97 (0.55) | SIGMAR1TMEM97PREPAADATFKBP1A | |
| SCHEMBL21864904 | 0.80 | PARP1 (0.49) | PARP1 | |
| SCHEMBL21809244 | 0.80 | PARP1 (0.49) | PARP1 | |
| SCHEMBL12600595 | 0.80 | TMEM97 (0.48) | SIGMAR1TMEM97PREPAADATFKBP1A | |
| SCHEMBL1061828 | 0.80 | TMEM97 (0.48) | SIGMAR1TMEM97PREPAADATFKBP1A | |
| SCHEMBL4033512 | 0.80 | TMEM97 (0.68) | SIGMAR1TMEM97PREPFKBP1A | |
| SCHEMBL27758911 | 0.80 | AADAT (0.49) | PARP1AADAT | |
| SCHEMBL29277932 | 0.79 | PREP (0.52) | SIGMAR1TMEM97PREPAADAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012876-A9 | SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY | — | 1997-09-18 | — | — | WO | claimed |
| EP-0906307-A4 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0906307-A1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | Merck & Co., Inc. (US) | 1999-04-07 | — | — | EP | disclosed |
| EP-0854870-A4 | SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0854870-A1 | SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY | Merck & Co., Inc. (US) | 1998-07-29 | — | — | EP | disclosed |
| WO-1997047618-A1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 1997-12-18 | — | — | WO | disclosed |
| WO-1997012876-A9 | SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY | — | 1997-09-18 | — | — | WO | disclosed |
| WO-1997012876-A1 | SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 1997-04-10 | — | — | WO | disclosed |