Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3068250 | 0.85 | PARP1 (0.47) | PARP1DPP4ADORA2AADORA1HTR2A | |
| SCHEMBL556764 | 0.82 | PARP1 (0.51) | PARP1DPP4ADORA2AADORA1HTR2A | |
| SCHEMBL20138342 | 0.81 | PARP1 (0.46) | PARP1DPP4ADORA2AADORA1HTR2A | |
| SCHEMBL763087 | 0.81 | PARP1 (0.50) | PARP1ADORA2AADORA1HTR2AHTR2C | |
| SCHEMBL1647056 | 0.81 | PARP1 (0.46) | PARP1DPP4ADORA2AADORA1HTR2A | |
| SCHEMBL3823364 | 0.81 | PARP1 (0.46) | PARP1DPP4ADORA2AADORA1HTR2A | |
| Hydrochloric Acid SCHEMBL9664729 | 0.79 | PARP1 (0.45) | PARP1DPP4ADORA2AADORA1HTR2A | |
| SCHEMBL7856462 | 0.78 | PARP1 (0.47) | PARP1DPP4ADORA2AADORA1HTR2A | |
| SCHEMBL29907256 | 0.78 | PARP1 (0.47) | PARP1DPP4ADORA2AADORA1HTR2A | |
| SCHEMBL23733959 | 0.77 | GABRA1 (0.44) | PARP1DPP4ADORA2AADORA1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1250326-A2 | INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR MEDIATING OR INHIBITING CELL PROLIFERATION | AGOURON PHARMACEUTICALS, INC. (US) | 2002-10-23 | — | — | EP | disclosed |
| WO-2001053268-A2 | INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR MEDIATING OR INHIBITING CELL PROLIFERATION | AGOURON PHARMACEUTICALS, INC. (US) | 2001-07-26 | — | — | WO | disclosed |