Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7563739 | 0.99 | REN (0.52) | RENMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7560414 | 0.85 | MAPT (0.43) | RENMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7549651 | 0.81 | REN (0.49) | RENMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7080518 | 0.81 | REN (0.55) | RENMAPTNPC1RAB9ASMN1; SMN2 | |
| Bromide SCHEMBL6041996 | 0.80 | REN (0.54) | RENMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6043263 | 0.78 | MAPT (0.40) | RENMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6041946 | 0.76 | REN (0.60) | RENMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6041513 | 0.76 | REN (0.59) | RENMAPTNPC1RAB9ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL6042392 | 0.75 | REN (0.70) | RENFFAR1 | |
| SCHEMBL7567638 | 0.75 | REN (0.48) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |